Sanity's Edge was a foray into a Lovecraft-esque world, sharing at least the locale of Miskatonic University. I conjured up Vernon Eldritch as the mysterious professor who researches the occult and arcane - and directs the party from the comfort of his cluttered office.
This campaign was short-lived, although it produced one of the best missions I've led. Read through the writeup of Faces in the Coal - once again, this is the power of role-playing. Dark gothic Americana, a prayer gone completely wrong, and the drink that "ain't exactly whiskey, and ain't exactly gin..."
The second mission was kind of forced and I didn't continue with the campaign. This was run in about 2015/2016.